Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2138334 | Leukemia Research | 2009 | 7 Pages |
Abstract
HLA-G is a non-classical HLA class I antigen primarily expressed in the extravillous cytotrophoblast. HLA-G can also be expressed at some pathological circumstances and may thus contribute to inhibition of efficient immune responses. Complex regulation of HLA-G expression also involves epigenetic mechanisms as DNA methylation. Here we demonstrate that treatment with demethylating agent 5-aza-2′-deoxycytidine (AdC) resulted in HLA-G transcription in 18 out of 20 examined leukemia cell lines. HLA-G protein synthesis was detected in 10 cell lines expressing significant level of HLA-G transcripts following AdC treatment.
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Authors
K. Poláková, E. Bandžuchová, D. Kuba, G. Russ,