Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2138383 | Leukemia Research | 2010 | 8 Pages |
Abstract
We used a novel high-throughput drug screening assay, based on Luminex technology, to identify anti-myeloma agents capable of inhibiting cytokines and growth factors essential for multiple myeloma (MM) from a chemical library of 1120 compounds provided by MMRF. Tetracycline derivatives inhibited MM cell proliferation and osteoclast activating factors without obvious effect on cell viability. Steroid compounds specifically decreased angiogenesis-related factors, but stimulated osteoclast activating factors. Antihelmintic drugs potently inhibited cytokines and were cytotoxic. The screen identified potential candidates with potent anti-MM properties that need further investigation.
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Authors
Rentian Feng, Jorge A. Rios, Tomifumi Onishi, Anna Lokshin, Elieser Gorelik, Suzanne Lentzsch,