Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2138459 | Leukemia Research | 2010 | 6 Pages |
Abstract
The microRNA/miR system might contribute to deregulation of cell homeostasis/disease phenotype. This is the first approach to generate an expression profile of 365 microRNAs in myelodysplastic syndromes (MDS) with normal karyotype (n = 12) and distinct cytogenetic aberrations (n = 12).In MDS-del(5q), a series of microRNAs not in the 5q-region was increased. MicroRNAs encoded on chromosomes 5, 7 and 8 were not differentially expressed in MDS with del(5q), −7 or +8. Evaluation in a larger cohort could confirm the up-regulation of the miR-1 in MDS.These findings provide evidence that MDS-haematopoiesis is distinct in its microRNA-expression pattern from non-neoplastic cells.
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Authors
Kais Hussein, Katharina Theophile, Guntram Büsche, Brigitte Schlegelberger, Gudrun Göhring, Hans Kreipe, Oliver Bock,