Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2138511 | Leukemia Research | 2007 | 8 Pages |
Abstract
Scutellaria baicalensis (S.B.) is a widely used Chinese herbal medicine. We initially investigated its in vitro anti-tumor activities. S.B inhibited the growth of ALL, lymphoma and myeloma cell lines by inducing apoptosis and cell cycle arrest at clinically achievable concentrations. The anti-proliferative effect was associated with mitochondrial damage, modulation of the Bcl family of genes, increased level of the CDK inhibitor p27KIP1 and decreased level of c-myc oncogene. HPLC analysis of S.B. showed it contains 21% baicalin and further studies confirmed it was the major anti-cancer component of S.B. Thus, Scutellaria baicalensis should be tested in clinical trials for these hematopoietic malignancies.
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Authors
Takashi Kumagai, Claudia I. Müller, Julian C. Desmond, Yasufumi Imai, David Heber, H. Phillip Koeffler,