| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2138534 | Leukemia Research | 2010 | 5 Pages |
Abstract
Wilms tumor gene (WT1) mRNA expression in peripheral blood cells was examined in 80 patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) transformed from MDS. Serum anti-WT1 antibody titers were also determined in 45 patients. Their long-term follow-up showed that the survival rate became worse as the WT1 mRNA level increased. In particular, a high WT1 mRNA level was a strong predictor of a short time to AML transformation even if adjusted by the International Prognostic Scoring System category. Moreover, high values of anti-WT1 antibody were an independent predictor of longer survival. These data may justify therapeutic strategies targeting WT1 molecules in MDS.
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Authors
Hideto Tamura, Kazuo Dan, Norio Yokose, Rika Iwakiri, Masatsugu Ohta, Hisashi Sakamaki, Kaoru Tohyama, Asaka Kondo, Hideya Hyodo, Kyoko Nakamura, Taishi Yamashita, Olga A. Elisseeva, Yoshihiro Oka, Yusuke Oji, Haruo Sugiyama, Kiyoyuki Ogata,