Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2138538 | Leukemia Research | 2010 | 5 Pages |
Abstract
Centrosome amplification (CA) as a potential marker of mitotic disruptions in multiple myeloma (MM) was investigated in two populations of B-cell lineage: B-cells and plasma cells (PCs). Using immunofluorescent staining, it was shown that CA in B-cells is present in 3.2 ± 2.5% in healthy donors versus 9.9 ± 7.9% in MM patients (p < 0.0001). Based on the calculated threshold value of CA in B-cells, 37% (14/38) of MM patients were positive. There was no significant correlation between CA-positive MM cases (based on PC samples evaluation) and the occurrence of cytogenetic abnormalities in PCs, including del(13)(q14), del(17)(p13), gain(1)(q21) and hyperdiploidy.
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Authors
E. Dementyeva, P. Nemec, F. Kryukov, K.R. Muthu Raja, J. Smetana, R. Zaoralova, H. Greslikova, R. Kupska, P. Kuglik, R. Hajek,