Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2138584 | Leukemia Research | 2009 | 11 Pages |
Abstract
In children with acute lymphoblastic leukemia (ALL), leukemic cells express several members of the VEGF family and the three VEGF receptors which, via an autocrine loop are responsible for secretion of MMP-2/-9. MMP activity and the presence of elements of the autocrine loop are correlated with clinical and prognostic parameters as follows: i) high basal MMP-9 activity with tumoral syndrome, ii) MMP-2 activity with treatment failure, iii) VEGFR-1/-3 co-expression with high hemoglobin level and iv) expression of the VEGF-A 121 isoform and favorable response to treatment. These data implicate autocrine VEGF-induced secretion of MMP-2/-9 in the physiopathology of childhood ALL.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Florent Poyer, Bérénice Coquerel, Rassa Pegahi, Lionel Cazin, Vic Norris, Jean-Pierre Vannier, Marek Lamacz,