Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2138655 | Leukemia Research | 2006 | 10 Pages |
Abstract
Spontaneous in vitro apoptosis reflects a true biological heterogeneity between patients which has to be considered when in vitro models are used to study regulation of apoptosis in native human AML cells. Even though the balance between pro- and anti-apoptotic signaling seems to have a prognostic impact in AML, the possible clinical relevance of spontaneous apoptosis remains to be clarified. High apoptosis/low viability was associated with low levels of heat shock proteins 70 and 90 as well as low Bcl-2:Bax ratio for patients heterogeneous with regard to morphology, membrane molecule expression, genetic abnormalities and response to therapy.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Anita Ryningen, Elisabeth Ersvær, Anne Margrete Øyan, Karl-Henning Kalland, Olav Karsten Vintermyr, Bjørn Tore Gjertsen, Øystein Bruserud,