Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2138729 | Leukemia Research | 2010 | 8 Pages |
Abstract
To study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport. Sex-adjusted analysis showed NQO1 609CT significantly protects against ALL, whilst MTHFR 677CT confers marginal protection. Interestingly, we observed that NQO1 609CT and MTHFR 1298 C-allele have greater genetic impact in boys than in girls. The combination of SLC19A1 80GA heterozygosity and 3′-TYMS −6 bp/−6 bp homozygous deletion is associated with reduced ALL risk in Malay boys. Our study has suggested the importance of gender and race in modulating ALL susceptibility via the folate metabolic pathway.
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Authors
Allen Eng-Juh Yeoh, Yi Lu, Jason Yong-Sheng Chan, Yiong Huak Chan, Hany Ariffin, Shirley Kow-Yin Kham, Thuan Chong Quah,