Article ID Journal Published Year Pages File Type
2138776 Leukemia Research 2006 5 Pages PDF
Abstract

We have previously shown that troglitazone (TG) induces apoptosis in acute myelogenous leukaemia (AML) cell lines. Here we show that normal bone marrow and mobilized peripheral blood progenitors are highly resistant to TG at concentrations up to 100 μM, while primary cultures of AML bone marrow show significant decline in viability at >7.5 μM TG. The combination of standard cytotoxic agents (daunorubicin, etoposide, and cytarabine) with TG is synergistic in six AML cell lines, with the strongest synergy being exhibited when cells are pretreated with TG for 24 h prior to addition of the cytotoxic agent. Significant declines in IC50 for the cytotoxic agents are seen at nanomolar concentrations of TG. The in vitro synergy between TG and the cytotoxic drugs used in AML therapy provides a basis for in vivo evaluation of these combinations.

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