Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2138877 | Leukemia Research | 2009 | 7 Pages |
Abstract
Renin–angiotensin system (RAS) in the bone marrow is related to proliferation and cellular differentiation. We investigated the effect of ACE inhibitors (ACEI) captopril (>1 mM) and trandolapril (>0.05 mM) and losartan (0.2 mM) on K562 cell line and K562 transfected with c-myc, bcl-x and bcl-2 (KmycB, Kbclx and Kbcl2 respectively). RAS components, proliferation, apoptosis and c-myc expression were analyzed. ACEI and losartan inhibited cell growth, decreased c-myc expression and increased apoptosis. These effects seem to be associated to angiotensin II-induced Smad activation. This work offers a new possible line of treatment for some acute myeloid leukemias and a new area of clinical research.
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Authors
Silvia De la Iglesia Iñigo, Carmen Elsa López-Jorge, Maria Teresa Gómez-Casares, Angelina Lemes Castellano, Pedro Martín Cabrera, Jezabel López Brito, Alexia Suárez Cabrera, Teresa Molero Labarta,