Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2138924 | Leukemia Research | 2006 | 7 Pages |
Abstract
To clarify whether expression of the programmed cell death 5 (PDCD5) gene in leukemic cells is abnormal, real-time quantitative reverse transcription polymerase chain reaction (RQ-RT-PCR) was used to examine its expression in marrow cells from leukemia patients. We found lower PDCD5 in both AML and CML marrow cells than in normal donor marrow cells. A negative correlation was found between relative levels of PDCD5 and BCR/ABL expression in all CML patients and in CML patients in the advanced phase. Treatment with the ABL tyrosine kinase inhibitor Imatinib mesylate increased PDCD5 expression in K562 and MEG-01 cells. These findings suggest that abnormal expression of PDCD5 in leukemia may be involved in the pathomechanism of AML and CML.
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Authors
Guo-Rui Ruan, Ya-Zhen Qin, Shan-Shan Chen, Jin-Lan Li, Xi Ma, Yan Chang, Ya-Zhe Wang, Jia-Yu Fu, Yan-Rong Liu,