Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2139099 | Leukemia Research | 2008 | 6 Pages |
Abstract
Bone marrow necrosis is a rare cause of bone marrow failure. Malignancy is the most frequent cause of bone marrow necrosis. Among malignancies, non-Hodgkin lymphoma (NHL) accounts for 10% of cases of bone marrow necrosis. Virtually all reported cases of NHL-associated bone marrow necrosis have developed in immunocompetent hosts. We report on a case of bone marrow necrosis complicating post-transplant lymphoproliferative disorder (PTLD) and resolving after rituximab monotherapy. This case report provides the first evidence of (i) bone marrow necrosis as a complication of PTLD; (ii) rapid resolution of NHL-associated bone marrow necrosis after rituximab treatment.
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Authors
Davide Rossi, Antonio Ramponi, Silvia Franceschetti, Piero Stratta, Gianluca Gaidano,