Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2139274 | Leukemia Research | 2008 | 8 Pages |
Abstract
In contrast to solid tumors, leukemic blasts frequently present both Hsp70 and HLA-E on their cell surface and thereby present activating and inhibitory signals to CD94+ NK cells. In the first 12 months after stem cell transplantation (SCT) CD94+ NK cells clearly dominate over CD3+/CD16−/56− T and CD3+/CD16+/56+ NK-like T cells. An incubation of post-SCT-derived peripheral blood lymphocytes with the Hsp70 peptide TKD and IL-15 enhances the cell surface density of CD56/CD94 and initiates the cytolytic activity of NK cells against Hsp70/HLA-E double-positive autologous and allogeneic leukemic blasts. Hsp70 was identified as the target structure for TKD-activated NK cells.
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Authors
Catharina Gross, Ernst Holler, Stefan Stangl, Anne Dickinson, A. Graham Pockley, Alexzander A. Asea, Nagaraja Mallappa, Gabriele Multhoff,