Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2139278 | Leukemia Research | 2008 | 9 Pages |
Abstract
Malignant transformation is known to be associated with changes in cell surface carbohydrate-architecture, which can be detected by lectins. In the present study, Maackia amurensis agglutinin (MAA), specific for NeuNAcα(2 â 3)Gal/GalNAc showed strong binding with lymphoblasts of children having acute lymphoblastic leukemia (ALL) as compared to cells from children with non-hematological disorders (“Controls”). MAA recognized a 66 kDa sialoglycoprotein present in membrane fraction of ALL cells. Moreover, MAA induced apoptosis in ALL cells was found to be reduced significantly in presence of GM2/IgGMAA. Thus, MAA has a potential to be used as diagnostic and therapeutic agent in case of childhood-ALL.
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Authors
Sarika Kapoor, Ram Marwaha, Siddhartha Majumdar, Sujata Ghosh,