Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2139321 | Leukemia Research | 2008 | 4 Pages |
Abstract
The acronym POEMS refers to polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes. This disease is progressive and weakening for patients and lead to death generally for neurological problem without therapy. We treated four patients affected by POEMS syndrome with front-line chemotherapy and autologous peripheral blood stem cell transplantation (aPBSCT). After a median follow-up of 40.5 months (range 12–52), all patients are alive with slow but progressive improvement in neurological disease, skin changes, performance status and without evidence of clonal plasmacytosis and organomegaly. In conclusion early diagnosis is crucial to obtain best response and improve clinical outcome.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Luca Laurenti, Silvia De Matteis, Mario Sabatelli, Amelia Conte, Patrizia Chiusolo, Federica Sorà, Nicola Piccirillo, Tommaso Za, Michela Tarnani, Elena Rossi, Giuseppe Leone, Simona Sica,