| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2139338 | Leukemia Research | 2006 | 4 Pages |
Abstract
During normal B-lymphocyte development once cells pass the pro-B stage the transcription factor LEF-1, a key component of the Wnt/β-catenin pathway, is down regulated. However studies have shown that B-cell chronic lymphocytic leukaemia (CLL) lymphocytes, which have a mature B-cell phenotype, still express abundant LEF-1. This study demonstrates that although LEF-1 mRNA is universally, highly expressed in B-CLL, expression of this gene is much lower or absent in the majority of low-grade B-cell non-Hodgkin's lymphoma (NHL). This suggests that there exist key differences in the activity of the Wnt/β-catenin pathway between low-grade B-cell malignancies.
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Authors
Denise Howe, Teresa Bromidge,