Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2139404 | Leukemia Research | 2007 | 8 Pages |
Abstract
The association between the â76GÂ >Â C in the 5â²-flanking region and 723TÂ >Â G in JWA exon three variants were examined for risk of leukemia development in a hospital-based case-control study of 201 leukemia patients and 243 cancer-free controls in a Chinese population. Studies showed that the â76C allele was associated with significantly increased odds of leukemia but the 723G allele was correlated with marked decreased odds of leukemia. Variation in the â76C allele resulted in almost complete loss of oxidative stress stimulated transcription activities of the promoter fragment.
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Authors
Qun Shen, Wei-Yan Tang, Chun-Ping Li, Rui Chen, Yu-Jie Zhu, Shu Huang, Ai-Ping Li, Jian-Wei Zhou,