| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2139430 | Leukemia Research | 2008 | 6 Pages |
Abstract
The frequencies of TT and CT genotypes were two-fold higher in Dutch children. The TSER 3R/3R repeat was three-fold more frequent in the Indonesian children, while the 2R/2R repeat was only 1% compared to 21% in the Dutch children. No differences of these polymorphisms were found between ALL cells and normal blood cells, indicating an ethnic rather than leukemic origin. These results may have implications for treatment of Indonesian children with ALL.
Keywords
SHMTMTXDHFMTHFRDTTPS-adenosylhomocysteineSAHDDHMTRRdihydrofolateSAMFdUMPTHFMTHFR C677TDTMPTSER5,10-Methylenetetrahydrofolatedhfrdouble distilled waterS-adenosylmethionineIndonesiaPaediatric patientstetrahydrofolatedeoxythymidine monophosphatedeoxyuridine monophosphatedeoxythymidine triphosphatedihydrofolate reductasedUMPthymidylate synthaseAcute lymphoblastic leukemiaMethotrexateMethylenetetrahydrofolate reductaseMethionine synthasemethionine synthase reductaseALLpolymerase chain reactionPCR
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Authors
Elisa Giovannetti, Dewa G. Ugrasena, Eddy Supriyadi, Laura Vroling, Antonino Azzarello, Desiree de Lange, Godefridus J. Peters, Anjo J.P. Veerman, Jacqueline Cloos,