Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2139433 | Leukemia Research | 2008 | 5 Pages |
Abstract
The G-band cryptic t(12;21)(p13;q22) is the most common chromosomal rearrangement in childhood acute lymphoblastic leukemia (ALL). To investigate the nature of additional chromosomal events in this group of patients spectral karyotyping (SKY) following G-banding analysis was performed in 14 cases. From these cases six showed structural aberrations of chromosome 6, including both simple deletions and unbalanced translocations, and involved both q (n = 4) and p (n = 3) arms. The results show that rearrangements of 6p are also non-random events t(12;21)-positive ALL. This study illustrates the value of a combined SKY and G-banding approach in identifying novel karyotypic events in childhood ALL.
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Authors
David R. Betts, Racheli Stanchescu, Felix K. Niggli, Ninette Cohen, Gideon Rechavi, Ninette Amariglio, Luba Trakhtenbrot,