Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2139579 | Leukemia Research | 2007 | 8 Pages |
Abstract
A novel bone biopsy technique was used to generate a robust stromal cell system to study how stroma modulates CLL B-cell apoptosis and how the leukemic cell–stromal interaction influences secretion of vascular factors. Marrow stromal elements (MSE) rescued CLL B-cells from both spontaneous and drug induced apoptosis, partly due to soluble factors. When CLL B-cells were added to the MSE cultures, a dramatic increase in the secretion of basic fibroblast growth factor and decrease in the secretion of thrombospondin was observed. These results indicate the interaction between CLL B-cells and marrow stromal elements regulates angiogenic switching and may be linked to disease progression.
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Authors
Neil E. Kay, Tait D. Shanafelt, Ann K. Strege, Yean K. Lee, Nancy D. Bone, Azra Raza,