Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2139583 | Leukemia Research | 2007 | 8 Pages |
Abstract
Microarray-based gene expression analysis was performed on diagnostic chronic phase CML patient samples prior to interferon treatment. Fifteen patient samples corresponding to six cytogenetic responders and nine non-responders were included. Genes differentially expressed between responder and non-responder patients were listed and a subsequent leave-one-out cross validation (LOOV) procedure showed that the top 20 genes allowed the highest prediction accuracy. The relevant genes were quantified by real-time PCR that supported the microarray results. We conclude that it might be possible to use gene expression analysis to predict future response to interferon in CML diagnostic samples.
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Authors
Anette Hagberg, Ulla Olsson-Strömberg, Ulrika Wickenberg-Bolin, Hanna Göransson, Anders Isaksson, Mats Bengtsson, Martin Höglund, Bengt Simonsson, Gisela Barbany,