Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2139587 | Leukemia Research | 2007 | 10 Pages |
Abstract
Dequalinium (DQA) has been proposed as a selective antitumoral agent due to its preferential accumulation in mitochondria of cancer cells. Our aim was a better understanding of DQA cytotoxicity. DQA-induced NB4 and K562 cell alterations are initiated within the first 30Â min of treatment at a high DQA concentration with a mitochondrial membrane depolarization. Cytochrome c release to cytoplasm, superoxide anion overproduction and ATP depletion in NB4 cells induce, 16Â h later, apoptosis by a typical caspase-9/caspase-3-dependent intrinsic pathway. K562 cells were more resistant to the DQA effect than NB4 cells, remaining viable for longer time periods.
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Authors
Pilar Sancho, Eva Galeano, Elena Nieto, M. Dolores Delgado, Ana Isabel GarcÃa-Pérez,