| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2139770 | Leukemia Research | 2007 | 4 Pages |
Abstract
Platelet-activating factor (PAF) is a phospholipid mediator with potent immunoregulatory activities on mature leukocytes. PAF modulates leukocyte cytosolic Ca2+ concentration ([Ca2+]i) through a Gq mediated pathway. We highlight, for the first time, Gq transcripts, PAF receptor (PAF-R) transcripts and protein in blast cells of acute myeloid (AML) and lymphoid (ALL) leukemia patients. PAF stimulated [Ca2+]i in leukemic blast cells; PAF effects being prevented by a specific PAF-R antagonist. In conclusion, functional PAF-R are present in blast cells of patients with acute leukemia; a result that could be of physiologic importance regarding the important effect of PAF on leukocytes maturation and functions.
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Authors
Stéphane Reynaud, Emilie Malissein, Magali Donnard, Dominique Bordessoule, Pascal Turlure, Franck Trimoreau, Yves Denizot,