Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2140143 | Leukemia Research | 2007 | 9 Pages |
Abstract
We analyzed complex chromosomal aberrations in 37 adult patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) using classical cytogenetic method, FISH with locus-specific probes, multicolor FISH (mFISH) and multicolor banding (mBAND). Unbalanced structural aberrations, leading to a gain or loss of chromosomal material, were frequently observed in bone marrow cells. In 30 patients (81.1%) loss or rearrangement of chromosome 5, 7 and/or 11 was found. The most frequent numerical change was trisomy 8 as expected (detected in six patients-16.2%) and the most frequent breakpoints 5q13, 5q33, 7q31, 10p12, 11q23, 12p13, 17p11 and 21q22 were determined.
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Authors
Libuse Babicka, Sarka Ransdorfova, Jana Brezinova, Zuzana Zemanova, Lenka Sindelarova, Magda Siskova, Jacqueline Maaloufova, Jaroslav Cermak, Kyra Michalova,