Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2140182 | Leukemia Research | 2006 | 7 Pages |
Abstract
Myelodysplastic syndrome (MDS) comprises a group of clonal haematopoietic disorders characterized by peripheral blood cytopenias, bone marrow hypercellularity, and abnormal blood cell differentiation. Approximately 30% of cases of MDS eventually progress to acute myelogenous leukemia (AML), while progression of MDS into acute lymphoblastic leukemia (ALL) is rare. In this report, we describe a case of MDS that progressed to ALL, and review the 21 previously reported cases of MDS to ALL transformation. We review the cancer stem cell model and its application to these disorders, and discuss the implications of the rarity of transformation of MDS to ALL for the biology of MDS and the pathogenesis of ALL.
Keywords
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Authors
Patricia Disperati, Christine V. Ichim, Douglas Tkachuk, Kathy Chun, Andre C. Schuh, Richard A. Wells,