Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2140270 | Leukemia Research Reports | 2016 | 5 Pages |
Abstract
•The case demonstrated a rare event of clonal heterogeneity by IKZF1 gene status in BCRABL1- ALL.•IKZF1 deletions are secondary events in ALL caused by clonal evolution during the treatment.•It's prognostic significance could be more crucial in BCR-ABL- rather than in BCR-ABL + ALL.•IKZF1 gene alterations may be determined and proved at the genome, expression and protein level.•IKZF1 deletions are suitable for MRD detection but not stable compared to Ig/TCR rearrangement.
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Authors
Volha Vshyukova, Alexander Meleshko, Natalia Mihal, Olga Aleinikova,