Article ID Journal Published Year Pages File Type
2140309 Leukemia Research Reports 2015 4 Pages PDF
Abstract

•YPEL5–PPP1CB is a chimeric transcript detected in CLL.•We detect this transcript also in non-CLL samples.•This marker is not suitable for diagnostic purposes of CLL.

Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5–PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease.

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Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
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