Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2140309 | Leukemia Research Reports | 2015 | 4 Pages |
•YPEL5–PPP1CB is a chimeric transcript detected in CLL.•We detect this transcript also in non-CLL samples.•This marker is not suitable for diagnostic purposes of CLL.
Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5–PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease.