Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2140333 | Leukemia Research Reports | 2013 | 4 Pages |
Abstract
Most patients now receiving a haematopoietic stem cell transplant (HSCT) for chronic myeloid leukaemia (CML) have been treated with first and second line TKIs pre-HSCT, raising concerns that these patients will have more resistant disease and accumulated greater toxicity from sequential lines of therapy, potentially compromising their outcome. We outline a series of 9 patients treated with imatinib then second generation TKIs for CML followed by HSCT and compare their outcomes with patients receiving imatinib-only pre-HSCT. Our case series demonstrates that second line and sequential tyrosine kinase inhibitors followed by HSCT is a safe and effective therapeutic approach for high risk CML.
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Authors
Anne-Louise Latif, Grant McQuaker, Anne Parker, Andrew Clark, Mhairi Copland,