Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2140343 | Leukemia Research Reports | 2013 | 4 Pages |
Abstract
Rabbit antithymocyte globulin (Thymoglobulin®) is commonly used as graft-versus-host disease (GvHD) prophylaxis. Since we found similar total CD8 T cell numbers in patients with and without Thymoglobulin® therapy within the first six months after allogeneic hematopoietic stem cell transplantation, we have analyzed the reconstitution of the CD8 T cell compartment in detail. After T cell-depletion, higher and more sustained proliferative capacity of memory CD8 T cells resulted in their rapid expansion, whereas the fraction of naive CD8 T cells decreased. Importantly, this shift towards effector memory CD8 T cells did not accelerate the incidence of GvHD.
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Authors
Friedrich Wittenbecher, Kathrin Rieger, Mikalai Dziubianau, Anne Herholz, Angela Mensen, Igor Wolfgang Blau, Lutz Uharek, Bernd Dörken, Andreas Thiel, Il-Kang Na,