Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2140354 | Leukemia Research Reports | 2014 | 4 Pages |
Abstract
Non-myeloablative allogeneic transplant (NMAT) has a curative potential for patients who are not myeloablative allogeneic transplant (MAT) candidates. We report a phase II trial of a NMAT regimen with cyclophosphamide and fludarabine in 40 patients; 21 of whom had a prior MAT. Day +100 and 1-year transplant-related mortality (TRM) post-NMAT were 13% and 34%, respectively. Day +100 and 1-year Overall/Progression-Free Survival (OS/PFS) were 80%/65% and 43%/25%, respectively. OS was higher in patients with KPSâ¥90 and lower in recipient/donor CMV+/â vs. other combinations. FluCy has low TRM and is curative in about 20% of high-risk patients.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Pamela Paplham, Theresa Hahn, Karen Dubel, Patricia Lipka, Philip L. McCarthy,