| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2140741 | Lung Cancer | 2015 | 9 Pages |
Abstract
We found that TGF-β-activated SMAD3/4 complex may upregulate CDH2 expression by directly interacting with a specific SMAD-binding element in CDH2 promoter. Our findings provide insights into mechanisms underlying the transcriptional regulation of CDH2 expression in TGF-β-induced EMT and SMADs-based therapeutic strategies for NSCLCs.
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Authors
Haiping Yang, Longqiang Wang, Jun Zhao, Yongbing Chen, Zhe Lei, Xia Liu, Wei Xia, Lingling Guo, Hong-Tao Zhang,