Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2143544 | Lung Cancer | 2008 | 6 Pages |
SummarySixty-one non-small cell lung cancer (NSCLC) patients with stage II and III/IV were enrolled and 49 completed immunotherapy. Patients were grouped based on immunosuppressive acidic protein (IAP). All patients received monthly intravenous infusions containing 1 × 1010 (mean cell number per patient) ex vivo expanded and IFN-α-treated peripheral blood mononuclear cells. No patients had grade 2 or greater adverse events. The patients with ≤580 μg/ml of serum IAP levels (n = 33) had significantly longer recurrence-free survival than those with >580 μg/ml of serum IAP levels (n = 16). Patients with lower IAP levels are still under immunotherapeutic control after 27 months free of recurrence. The IAP levels may be a prognostic marker for treatment efficacy in NSCLC. This immunotherapeutic regimen was feasible and well tolerated in patients with advanced NSCLC in terms of prolongation of survival.