Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2143545 | Lung Cancer | 2008 | 7 Pages |
SummaryIntroductionThe longest survival time reported in randomised trials of limited disease (LD) SCLC has been achieved with early twice-daily concurrent chemoradiation. Topotecan is active in recurrent SCLC and in extensive disease as first line treatment. Aim: To incorporate and assess the effect of topotecan with concurrent twice-daily radiochemotherapy in LD SCLC.Patient and MethodsMulticentre phase II study of three cycles of regimen A (topotecan i.v., 1.5 mg/m2, day 1–5; cisplatin 50 mg/m2, day 1) and three cycles of regimen B (etoposide i.v., 120 mg/m2, day 1–3; carboplatin, AUC = 5, day 1; vincristine, 1.3 mg/m2, day 1) given in the following sequence: A–B–B–A–B–A every 21 days. Twice-daily radiotherapy (1.5 Gy × 30, 10 fr/wk, 45 Gy) was delivered concurrently with the first cycle B. Prophylactic cranial irradiation was offered to patients (pts) in complete remission. Eligible were pts with LD SCLC with no prior treatment for SCLC, adequate organ functions, and WHO performance status (PS) ≤2. Pts older than 64 years with PS = 2 and LDH > two times the upper limit were excluded.ResultFourty-five pts were included in four centres. Five patients did not meet the inclusion criteria. The median age of the eligible pts was 60 years, range 43–75. PS was ≤1 in 90% of pts. Non-haematological toxicity was mild except grade 3 esophagitis, which was observed in 26.5% of pts. One pt developed an esophageal stricture. Grade 3/4 leucopenia and thrombocytopenia were observed in 82.5% and 75.0 of pts, respectively. One patient died due to neutropenic sepsis. The overall response rate was 77.5% with 30.0% achieving a complete response. Median progression-free survival was 11.8 months (95% CI: 1.3–22.2). Median overall survival was 22.9 months (95% CI: 13.4–31.5) and 5-year survival was 21%.ConclusionThe combination of topotecan and cisplatin with concurrent twice-daily chemoradiation results in long-term survivors. As expected the incidence of severe esophagitis is high.