| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2144147 | Lung Cancer | 2006 | 8 Pages |
SummaryBackgroundTo evaluate feasibility and safety of induction three-drugs combination chemotherapy and concurrent radio-chemotherapy in stage IIIB NSCLC.Patients and MethodsPatients with stage IIIB NSCLC were treated with three courses of induction chemotherapy, cisplatin 50 mg/m2, paclitaxel 125 mg/m2 and gemcitabine 1000 mg/m2 on days 1,8 of every 21 day cycle. Patients without distant progressive disease were then treated with radiotherapy and concurrent weekly gemcitabine (250 mg/m2). Toxicity and response of radio-chemotherapy treatment have been assessed.ResultsBetween Jan 01 and Nov 02, 46 patients were enrolled. Grade 3+ hematological and non-hematological toxicity during the induction phase were 41.3% and 13.1%, respectively. In 38 patients a Clinical Response or Stable Disease was recorded and these patients underwent to concurrent radio-chemotherapy. Grade 3+ hematological and non-hematological toxicities were 8.2% in this group. Further response was observed in 66% of patients. Overall median survival time was 17.8 months, with a 3-year survival rates of 23%.ConclusionThree-drugs induction chemotherapy and concurrent radio-chemotherapy with weekly gemcitabine in locally advanced stage IIIB NSCLC is feasible and safe.
