Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2144787 | Matrix Biology | 2014 | 12 Pages |
Abstract
Tenascins are extracellular matrix proteins with distinct spatial and temporal expression during development, tissue homeostasis and disease. Based on their expression patterns and knockout phenotypes an important role of tenascins in tissue formation, cell adhesion modulation, regulation of proliferation and differentiation has been demonstrated. All of these features are of importance in stem cell niches where a precise regulation of growth versus differentiation has to be guaranteed. In this review we summarize the expression and possible functions of tenascins in neural, epithelial and osteogenic stem cell niches during normal development and organ turnover, in the hematopoietic and pro-inflammatory niche as well as in the metastatic niche during cancer progression.
Keywords
MIRhuman umbilical vascular endothelial cellFNIIIfluorouracilTLR4SVZAPCHUVECECMTNCFBGLPSEGF5-FUHSCtenascin-Cantigen-presenting cellDkkdickkopfinflammationTenascinDevelopmentCancerHematopoietic stem cellDendritic cellNatural killer cellStem cell nicheepidermal growth factorfibronectin type IIIlipopolysaccharideExtracellular matrixCARsubventricular zoneMicroRNAHematopoiesisToll-like receptor 4
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Cancer Research
Authors
Ruth Chiquet-Ehrismann, Gertraud Orend, Matthias Chiquet, Richard P. Tucker, Kim S. Midwood,