| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2144816 | Matrix Biology | 2013 | 9 Pages |
Abstract
⺠Granzyme B generates multiple soluble fibronectin fragments from both plasma-derived and cell-derived fibronectin. ⺠Fibronectin proteolysis by granzyme B reduces endothelial cell adhesion and migration. ⺠Granzyme B disrupts capillary tube formation in 3D collagen gels. ⺠Using a small molecule granzyme B inhibitor restores the physiologic angiogenic potential of endothelial cells.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Alon Hendel, David J. Granville,