Glycosaminoglycan backbone is not required for the modulation of hemostasis: Effect of different heparin derivatives and non-glycosaminoglycan analogs

► Sulfated polysaccharides with different sequences, molecular weights and polymeric backbone modulate hemostasis ► Heparinomimetics bind to the same sites in ECs and SMCs suggesting a common pathway for ECM dependent biological activities. ► The synthetic heparin pentasaccharide binding studies are in agreement with its longer bioavailability. ► Sulfation alone is not sufficient for protein binding and biological activities of the polysaccharides studied. ► Redundancy could be observed among the tested compounds once seemingly distinct structures could support similar activities.