Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2145031 | Matrix Biology | 2008 | 8 Pages |
Abstract
Hyaluronidases are endoglycosidases that initiate the breakdown of hyaluronan (HA), an abundant component of the vertebrate extracellular matrix. In humans, six paralogous genes encoding hyaluronidase-like sequences have been identified on human chromosomes 3p21.3 (HYAL2–HYAL1–HYAL3) and 7q31.3 (SPAM1–HYAL4–HYALP1). Mutations in one of these genes, HYAL1, were reported in a patient with mucopolysaccharidosis (MPS) IX. Despite the broad distribution of HA, the HYAL1-deficient patient exhibited a mild phenotype, suggesting other hyaluronidase family members contribute to constitutive HA de
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Authors
Vasantha Atmuri, Dianna C. Martin, Richard Hemming, Alex Gutsol, Sharon Byers, Solmaz Sahebjam, James A. Thliveris, John S. Mort, Euridice Carmona, Judy E. Anderson, Shyamala Dakshinamurti, Barbara Triggs-Raine,