Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2145493 | Matrix Biology | 2006 | 11 Pages |
Abstract
These observations reveal that peptides of type II collagen, to which there is increased exposure in osteoarthritic cartilage, can when present in sufficient concentration induce cleavage of type II collagen (CB12-II) and aggrecan (CB12-IV) accompanied by increased expression of collagenases. Such increased concentrations of denatured collagen are present in adult and osteoarthritic cartilages and the exposure of chondrocytes to the sequences they encode, either in soluble or more likely insoluble form, may therefore play a role in the excessive resorption of matrix molecules that is seen in arthritis and development.
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Authors
Tadashi Yasuda, Elena Tchetina, Kunitaka Ohsawa, Peter J. Roughley, William Wu, Aisha Mousa, Mirela Ionescu, Isabelle Pidoux, A. Robin Poole,