Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2145632 | Molecular Oncology | 2010 | 12 Pages |
Abstract
The work demonstrates that other than gene amplification, a single somatic mutation in ACK1 can result in extended protein stability enabling the oncoprotein to exert its oncogenic function in tumor progression. It also provides a rationale to target ACK1 in combination with other chemotherapeutic drugs, such as EGFR inhibitors, to potentiate therapeutic action against resistant tumors.
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Authors
Boon Tin Chua, Shu Jing Lim, Su Chin Tham, Wei Jie Poh, Axel Ullrich,