Article ID Journal Published Year Pages File Type
2145721 Molecular Oncology 2013 12 Pages PDF
Abstract
► HMGA overexpression is causally involved in neoplastic transformation. ► The HMGA proteins regulate negatively miR-603 and positively miR-10b expression. ► miR-10b targets the PTEN gene, whereas miR-603 targets CCND1 and CCND2 genes. ► Functional studies show that these microRNAs affects cancer cell proliferation and migration.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
Preview
The High Mobility Group A proteins contribute to thyroid cell transformation by regulating miR-603 and miR-10b expression
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