Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2145721 | Molecular Oncology | 2013 | 12 Pages |
Abstract
⺠HMGA overexpression is causally involved in neoplastic transformation. ⺠The HMGA proteins regulate negatively miR-603 and positively miR-10b expression. ⺠miR-10b targets the PTEN gene, whereas miR-603 targets CCND1 and CCND2 genes. ⺠Functional studies show that these microRNAs affects cancer cell proliferation and migration.
Keywords
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Authors
Paula Mussnich, Daniela D'Angelo, Vincenza Leone, Carlo Maria Croce, Alfredo Fusco,