Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2145767 | Molecular Oncology | 2013 | 7 Pages |
Abstract
⺠Two mutations, one novel, in KIT exon 11 were identified in one GIST patient. ⺠KIT exon 11 PCR fragment subcloning showed the mutations were on the same allele. ⺠KIT receptor carries the two corresponding aminoacidic substitutions. ⺠Biochemical/in silico analyses showed double KIT mutant is Imatinib sensitive. ⺠The patient, Imatinib treated, continues to respond well to the therapy.
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Authors
Elena Conca, Claudia Miranda, Valentina Dal Col, Elena Fumagalli, Giuseppe Pelosi, Mara Mazzoni, Maurizio Fermeglia, Erik Laurini, Marco A. Pierotti, Silvana Pilotti, Angela Greco, Sabrina Pricl, Elena Tamborini,