Article ID Journal Published Year Pages File Type
2145767 Molecular Oncology 2013 7 Pages PDF
Abstract
► Two mutations, one novel, in KIT exon 11 were identified in one GIST patient. ► KIT exon 11 PCR fragment subcloning showed the mutations were on the same allele. ► KIT receptor carries the two corresponding aminoacidic substitutions. ► Biochemical/in silico analyses showed double KIT mutant is Imatinib sensitive. ► The patient, Imatinib treated, continues to respond well to the therapy.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
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