| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2145793 | Molecular Oncology | 2012 | 15 Pages |
Abstract
⺠Inducible PKN3 knockdown inhibits primary prostate and breast tumor growth. ⺠PKN3 associates with Rho-family GTPases, and preferentially with RhoC. ⺠RhoC predominantly associates with PKN3 compared to other PKN family members. ⺠PKN3 catalytic activity is stimulated in the presence of RhoA and RhoC. ⺠Turn-motif phosphorylation at T860 closely correlates with PKN3 activity.
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Authors
Keziban Unsal-Kacmaz, Shoba Ragunathan, Edward Rosfjord, Stephen Dann, Erik Upeslacis, Mary Grillo, Richard Hernandez, Fiona Mack, Anke Klippel,