Article ID Journal Published Year Pages File Type
2145797 Molecular Oncology 2012 14 Pages PDF
Abstract
► Shb is an adapter protein operating downstream of VEGFR-2. ► Shb was presently investigated in the context of RIP-Tag2 angiogenesis. ► Absence of Shb reduces RIP-Tag2 tumor burden and VEGF-dependent tumor angiogenesis. ► A fraction of tumors escape the angiogenic inhibition imposed by the absence of Shb. ► Tumor heterogeneity allows escape from angiogenic restriction by various means.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
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