Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2145797 | Molecular Oncology | 2012 | 14 Pages |
Abstract
⺠Shb is an adapter protein operating downstream of VEGFR-2. ⺠Shb was presently investigated in the context of RIP-Tag2 angiogenesis. ⺠Absence of Shb reduces RIP-Tag2 tumor burden and VEGF-dependent tumor angiogenesis. ⺠A fraction of tumors escape the angiogenic inhibition imposed by the absence of Shb. ⺠Tumor heterogeneity allows escape from angiogenic restriction by various means.
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Authors
Björn Ã
kerblom, Guangxiang Zang, Zhen W. Zhuang, Gabriela Calounova, Michael Simons, Michael Welsh,