| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2145991 | Molecular Oncology | 2011 | 9 Pages |
Abstract
⺠Aneuploidy is a tumorigenic process. ⺠Spindle checkpoint, mitotic proteins and p53/p73 determine efficiency of checkpoint. ⺠Inactive checkpoint, excess/deficit centrosomes or mis-cytokinesis cause tetraploidy. ⺠Tetraploid cells senesce, apoptosis or arrest, depending on the cellular context.
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Authors
Yael Aylon, Moshe Oren,