Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2146059 | Molecular Oncology | 2009 | 8 Pages |
Abstract
Epithelial ovarian cancers are typified by frequent genomic aberrations that have been difficult to unravel. Recently, high-resolution array technologies have provided the first glimpse of the remarkable complexity of these aberrations with some ovarian cancers containing hundreds of copy number breakpoints, micro-deletions and amplifications. Many of these alterations contain cancer-related genes suggesting that the majority is disease-associated and not just the product of random genomic instability. Future developments such as next-generation sequencing and integrated analysis of data from multiple array platforms on large numbers of samples are poised to revolutionise our understanding of this complex disease.
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Authors
Kylie L. Gorringe, Ian G. Campbell,