| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2146335 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2014 | 5 Pages |
Abstract
Telomere length was sequentially determined in peripheral blood leukocytes (PBL) from patients with ankylosing spondylitis (AS; n = 44) and psoriatic arthritis (PsA; n = 42) followed through 2.93 ± 0.99 years, using a quantitative PCR (qPCR) assay. The initial telomere size from PsA patients was higher than those with cutaneous psoriasis only (n = 53), possibly due to the inflammatory condition. The qPCR assay was sensitive enough to evidence a significant telomere length shortening in PBL from practically all subjects and PsA patients showed a higher rate of loss of telomere sequence than patients with AS during the follow-up time.
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Authors
María Tamayo, Sonia Pértega, Alejandro Mosquera, Montserrat Rodríguez, Francisco J. Blanco, José Luis Fernández-Sueiro, Jaime Gosálvez, José Luis Fernández,