| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2146572 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2011 | 10 Pages |
Abstract
⺠Hep G2 cells are failed to response in etoposide-induced cytotoxicity. ⺠Hep G2 cells persist with etoposide-induced DNA damage and escape G2/M arrest. ⺠Defects of Akt/PTEN axis are responsible for the survivability of Hep G2 cells. ⺠Overexpression of myr-Akt confers etoposide-induced survivability in cells. ⺠Thus, chemoresistivity of HCC may be associated with Akt/PTEN signaling pathway.
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Authors
Ananda Mukherjee, Saheli Samanta, Parimal Karmakar,