| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2146658 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2010 | 6 Pages |
PurposeThe XPC gene is involved in DNA damage recognition in the nucleotide excision repair pathway (NER). We investigated the additive effects of single nucleotide polymorphisms (SNPs) in bladder-cancer patients and population controls for three XPC polymorphisms: A499V (C > T), K939Q (A > C), and poly AT (PAT, −/+).Experimental Design311 bladder-cancer patients from a population-based cohort and 337 population controls were genotyped using the PCR-restriction fragment length polymorphism (RFLP) technique.ResultsWe found complete linkage between the K939Q (A > C) and PAT (−/+) polymorphisms and therefore only the K939Q (A > C) polymorphism was included in analyses. The over all estimated odds ratio was 1.7 (95% CI 1.3–2.4) for A499V (C > T
